How CBD Works & Potential Health Benefits

How CBD works

All cannabinoids, including CBD, attach themselves to certain receptors in the body to produce their effects.

The human body produces certain cannabinoids on its own. It has two receptors for cannabinoids, called CB1 receptors and CB2 receptors.

CB1 receptors are found all around the body, but many of them are in the brain.

The CB1 receptors in the brain deal with coordination and movement, pain, emotions and mood, thinking, appetite, and memories, among others. THC attaches to these receptors.

CB2 receptors are more common in the immune system. They have an effect on inflammation and pain.

It used to be thought that CBD acts on these CB2 receptors, but it appears now that CBD does not act on either receptor directly. Instead, it seems to influence the body to use more of its own cannabinoids.

Potential health benefits

Because of the way that CBD acts in the body, it has many potential uses. CBD oil is taken orally, rubbed on the skin, and sometimes inhaled through vapor or used intravenously to produce its effects.

Natural pain relief or anti-inflammatory properties

People commonly use prescription or over-the-counter drugs to relieve pain and stiffness, including chronic pain.

Some people feel that CBD offers a more natural way to lower pain. A study published in the Journal of Experimental Medicine found that CBD significantly reduced chronic inflammation and pain in some mice and rats.

The researchers suggest that the non-psychoactive compounds in marijuana, such as CBD, could be a new treatment for chronic pain.

CBD is already in use for some conditions that cause chronic pain, such as multiple sclerosis and fibromyalgia.

Quitting smoking and drug withdrawals

There is some promising evidence that CBD use may help people to quit smoking. A pilot studyposted to Addictive Behaviors found that smokers who used an inhaler containing the compound CBD smoked fewer cigarettes but did not have any additional craving for nicotine.

Another similar study posted to Neurotherapeutics found that CBD may be a promising substance for people who abuse opioids.

Researchers noted that some symptoms experienced by patients with substance use disorders may be reduced by CBD. These include anxiety, mood symptoms, pain, and insomnia.

These are early findings, but they suggest that CBD may be used to avoid or reduce withdrawal symptoms.

Epilepsy and other mental health disorders

CBD is also being studied for its possible role in treating epilepsy and neuropsychiatric disorders.

review posted to Epilepsia noted that CBD has anti-seizure properties and a low risk of side effects for people with epilepsy.

Studies into CBD’s effect on neurological disorders suggest that it may help to treat many of the disorders that are linked to epilepsy, such as neurodegeneration, neuronal injury, and psychiatric diseases.

Another study posted to Current Pharmaceutical Design found that CBD may have similar effects to certain antipsychotic drugs, and that it may be safe and effective in treating patients with schizophrenia.

More research is needed to understand how this works, however.

Helps fight cancer

CBD has been studied for its use as an anti-cancer agent.

review posted to the British Journal of Clinical Pharmacology notes that CBD appears to block cancer cells from spreading around the body and invading an area entirely.

The review indicates that CBD tends to suppress the growth of cancer cells and promote the death of these cells.

Researchers note that CBD may help in cancer treatment because of its low toxicity levels. They call for it to be studied along with standard treatments, to check for synergistic effects.

Anxiety disorders

Patients with chronic anxiety are often advised to avoid cannabis, as THC can trigger or amplify anxiety and paranoia in some people.

However, a review from Neurotherapeutics suggests that CBD may help to reduce the anxiety felt by people with certain anxiety disorders.

The researchers point to studies showing that CBD may reduce anxiety behaviors in disorders such as:

The review notes that current medications for these disorders can lead to additional symptoms and side effects, and that people may stop taking the drugs because of these unwanted effects.

CBD has not shown any adverse effects in these cases to date, and the researchers call for CBD to be studied as a potential treatment method.

Type 1 diabetes

Type 1 diabetes is caused by inflammation when the immune system attacks cells in the pancreas.

Recent research posted to Clinical Hemorheology and Microcirculation found that CBD may ease the inflammation in the pancreas in type 1 diabetes. This may be the first step in finding a CBD-based treatment for type 1 diabetes.

Acne

Another promising use for CBD is as a new treatment for acne. Acne is caused, in part, by inflammation and overworked sebaceous glands on the body.

A recent study posted to the Journal of Clinical Investigation found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect on the body.

CBD could be a future treatment for acne vulgaris, the most common form of acne.

Alzheimer’s disease

Initial research published in the Journal of Alzheimer’s Disease found that CBD was able to prevent the development of social recognition deficit in subjects.

This means that CBD could potentially prevent people in the early stages of Alzheimer’s from losing their ability to recognize the faces of people that they know. This is the first evidence that CBD has potential to prevent Alzheimer’s disease symptoms.

Last updated Sat 29 April 2017
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What are Cannabis Extracts

Portrait of Matt Price by Matt Price

Cannabis concentrates, commonly referred to as cannabis extracts, are significantly more potent than your standard cannabis buds. Their applications as medicine have proven to be effective for patients suffering from all sorts of ailments. When made properly, a cannabis concentrate is reminiscent of the cannabis strain it was extracted from; the smell, taste, and effects are simply magnified due to a larger concentration by weight.

The extraction of cannabis concentrates is a complex and potentially dangerous process and should only be performed by trained professionals. This page describes the most widely used extraction methods and discusses the advantages of each.

Types of Cannabis Extracts

Kief

Kief is the simplest of concentrates. Kief is composed of the trichomes (the crystalline structures coating the outside surface of the flowers) broken away from the dried plant material, usually via specialized filtering screens and a little elbow grease. Kief is generally considered a lower-quality extract, but some top-flight extractors can produce an extremely clean and flavorful product using the dry sieve method. THC content can range from 20 percent to 60 percent.

 

Dry Sieve (Dry Sift)

A popular form of non-solvent hash is dry sieve (sometimes referred to as “dry sift”). Put simply, dry sieve is a refined version of kief that has been run through a series of screens so that only the trichome heads remain. Thanks in large part to the simplicity of the process, dry sieve is among the easiest ways to produce hash. After all, all that you need to produce quality dry sieve hash is a few good screens to filter out the plant matter, good starting material, and a little bit of time.

The level of quality is often determined by amount of plant matter and capitulate trichome stalks found in the final product. This process at its highest level yields nothing but the largest, most perfect trichome gland heads and none of the gland stems, plant matter, etc. that generally clouds the quicker, lower-quality kief extractions. The most pure dry sieve hash should melt completely when exposed to heat, known as full-melt dry sieve hash.

Hash

Hash made from the cannabis plant has been around for centuries, and there are plenty of processes in which hash can be made. Ice water extraction is one of the most common processes used to create quality non-solvent hash. The main goal and fundamental idea behind the ice water extraction process is to isolate the trichome heads, which house the essential oils of cannabis, from the stalks and plant matter that carry little-to-no medicinal value.

The quality of the resulting hash is often determined by the size of the isolated trichome heads and the extent to which it melts when heated (full-melt being the best). The most important part of the ice water extraction process is drying the final product. If not properly dried, the hash can develop mold and other forms of microbiological life that could potentially be harmful to your body.

The powdery kief that coats your cannabis flowers can be collected and pressed together to form hash. Additionally solvents like ice water or ethanol may be used to more effectively strip the cannabis plant of its cannabinoid-loaded trichomes. Though not as potent as BHO and other cannabis concentrates, hash remains a staple of cannabis culture around the world for its clean, all-natural extraction process.

Butane Hash Oil (BHO)

Butane Hash Oil, commonly referred to as BHO, is a type of cannabis concentrate made using butane as the main solvent. While a number of variables can determine the final consistency of BHO (mostly temperature), people use different names when referring to each of the different consistencies. Shatter for instance, refers to the glass-like consistency that often snaps or “shatters” when handled. Budder, honeycomb, crumble, and sap are also used to describe the different textures, though they all fall under the category of BHO.

Under this form of extraction, THC content can be as high as 80-90%. This makes BHO a popular choice for many medical marijuana patients suffering from chronic pain, sleep disorders, and other intractable symptoms. Always be sure that your oil is lab tested for purity, as improperly purged BHO may contain traces of butane, pesticides, or other unhealthy ingredients/contaminants.

Supercritical CO2 Oil

Carbon dioxide (CO2) is a supercritical fluid, meaning it converts into a liquid form when pressurized. At the same time, CO2 is a pure chemical substance that occurs naturally and leaves behind no residues. In fact, supercritical CO2 extraction is already a standard extraction method for the food, dry cleaning and herbal supplement industries. It is a common food additive as well.

The CO2 extraction process allows compounds to be extracted with low toxicity; it utilizes a high pressure vessel containing cannabis. Supercritical CO2 is inserted into the vessel and pumped through a filter where it is separated from the plant matter once the pressure is released. Next, the supercritical CO2 evaporates and is dissolved into the cannabinoids.

 

Rick Simpson Oil (RSO)

Also known as cannabis oil, hemp oil, Phoenix Tears, and Rick Simpson Oil (RSO), whole-plant cannabis oil can be orally administered or applied directly to the skin. Sublingual delivery is the preferred method of treatment for many cancer patients. Not only is it a convenient way to medicate, but intake through the oral mucosal membranes in your mouth provides for rapid and effective absorption directly into your systemic circulation because of the increased bioavailability of the cannabinoids.

Note: Whole-plant cannabis oil is not the same as “hemp seed oil.” Hemp seed oil is a cold-pressed oil made from the seeds of the hemp plant. It is rich with essential fatty oils and is used mostly for its nutritional benefits. You can easily buy it in health food stores. It often gets mislabeled as “hemp oil,” but it is not. True whole-plant oil derived from the cannabis plant, on the other hand, is made from the buds/flower of the female marijuana plant and is comprised of many different cannabinoids including THC, CBD, CBN, and more — in addition to terpenes and other compounds. Many other businesses now sell their own renditions of Rick Simpson Oil, some of which are high in THC while others contain only non-psychoactive compounds like CBD. Be sure to do your research before making/buying any RSO products.

 

Rosin

Rosin has been gaining a lot of traction in the medical cannabis community as of lately and for good reason. Rosin is a solid form of resin that is obtained by adding pressure & heat to vaporize volatile liquid terpenes, typically with an industrial heat press (or even a hair straightener for small batches).
The rosin technique is quick, simple and affordable, allowing anyone to create quality solventless hash in a matter of seconds. To get started making Rosin, you only need a few basic tools in order to create a quality finished product, but not nearly as many as you need with other extraction techniques.

 

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